@DarkVoid666
Are you running on windows 10 ? did u try to disable firewall and anti virus, it blocks maybe...
For the plugins I use plugin video : ePSXe gpu core 2.0.0 (go to configure and put resolution to x1 for test) and put the default settings (paramètres par défaut) to 'nice' (beau)
plugin sound : ePSxe spu core 2.0.0
CDRom : Mooby2 cd disk image driver 2.8 (I recommend)
bios : SCPH-7003 v3.0 but maybe others bios works (not try), then disable bios HLE.
Then go to Options : Overclocking CPU to 1
once all is config : go fichier (file) and launch Iso : select cue file
Try it and tell if i work if don't, try different plugins videos (try with Pete OpenGL2).
I am running on win7 64 bits, so maybe the configuration can change on different OS.